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Comfortis Plus

4.7 / 5
Reviews: 81
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Comfortis Plus Flea, heartworm, worming Tablets For Dogs

Comfortis Plus treats fleas and flea infestation in dogs and puppies. The chew also treats worms as well as controls heartworms. The unique beef flavoured chewable is easy to administer in dogs. Comfortis is highly effective and treats 98% of fleas within 4 hours of administration. Its fast acting formula starts killing fleas in only 30 minutes and also prevents re infestation. Comfortis Plus, when given monthly, prevents heartworm infection in dogs. Moreover, it controls Flea Allergy Dermatitis and protects dogs against other flea infested diseases.

How does it work?

Spinosad and Milbemycin oxime are the active ingredients in Comfortis Plus. Spinosad ingredient is from spinosyns class of insecticides that are non-antibacterial tetracyclic macrolides. Spinosad attacks the neurons which causes involuntary muscle contractions and eventually leads to paralysis. Hence, all the fleas are destroyed. It also prevents flea re-infestation in dogs and puppies. The other ingredient Milbemycin oxime works on intestinal worms and immature heartworms. Thus, it eliminates these parasites and protects dogs against harmful heartworm and common worm infections.

From the Manufacturer
Comfortis Plus Spinosad and milbemycin oxime
Fast-acting, reliable flea control
  • Starts killing fleas in just 30 minutes
  • Prevents deadly heartworm disease
  • Treats and controls adult hookworm, roundworm, and whipworm infections

Comfortis PLUS provides 3-in-1 parasite protection for your dog, with protection against fleas, heartworm and intestinal worms (excluding tapeworm). The treatment is suitable for dogs with flea allergy dermatitis and will provide fast-acting flea protection for the entire month. As a tablet, there are no restrictions with regards to your dog swimming or being washed, and it won't rub off on your furniture.

Important Information
  • Read product leaflet for full instructions
  • For use in dogs from 8 weeks of age and 2.3 kg
  • Comfortis PLUS should be administered with food for maximum effectiveness
  • Seek veterinary advice regarding the use of Comfortis PLUS in pregnant and lactating females, breeding males, and in dogs with pre-existing epilepsy
  • Concurrent use of Comfortis PLUS with high off-label doses of ivermectin is not recommended
  • Before starting Comfortis PLUS, you should have your veterinarian confirm that your dog does not have heartworm
  • The following adverse events have been recorded following administration of spinosad and milbemycin together: vomiting, pruritus, lethargy and diarrhoea
  • In some animals, Comfortis PLUS may be associated with vomiting. If vomiting occurs within an hour of administration, re-dose with another full dose.
Directions for Use

Comfortis PLUS should be administered monthly with food for maximum effectiveness.

Comfortis PLUS pack for dogs weighing Tablet strength Dose
2.3 – 4.5 kg 140 mg / 2.3 mg 1 tablet
4.6 – 9 kg 270 mg / 4.5 mg 1 tablet
9.1 – 18 kg 560 mg / 9.3 mg 1 tablet
18.1 – 27 kg 810 mg / 13.5 mg 1 tablet
27.1 – 54 kg 1620 mg / 27 mg 1 tablet

Dogs over 54 kg should be dosed with the appropriate combination of tablets.

  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.
  • An advanced treatment for fleas and worms
  • Provides protection against heartworms
  • Starts killing flea in just 30 minutes
  • Helps to treat and prevent flea infestation
  • Aids in the control of flea allergy dermatitis
  • Treats and prevents hookworms, roundworms and whipworms
  • Tasty chews easy to dose
  • For use in dogs only.
  • Keep out of reach of children and pets.
  • Read safety directions.
  • For animal treatment only.
  • Store it in a cool and dry place.
  • Should not be given to puppies less than 8 weeks of age.


  • No possible side effects of using this product.
Target species Dogs
Mode of administration Oral
Active Ingredients Spinosad, Milbemycin Oxime
Manufacturer Elanco
Brand Name Comfortis

APVMA Approval Number

Comfortis Plus Chewable Tablets For XSmall Dogs 2.3-4.5kg (Pink) 65208/108403
Comfortis Plus Chewable Tablets For Small Dogs 4.6-9kg (Orange) 65208/108403
Comfortis Plus Chewable Tablets For Medium Dogs 9.1-18kg (Green) 65204/108401
Comfortis Plus Chewable Tablets For Large Dogs 18.1-27kg (Blue) 65203/108399
Comfortis Plus Chewable Tablets For XLarge Dogs 27.1-54kg (Brown) 65205/108398
Product Reviews
Reviews: 81
5 Star 4 Star 3 Star 2 Star 1 Star

Comfortis Plus

Comfortis Plus

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Pet care

Fabulous product and company..even made a mistake once in fuss return.


All in one

I don't need to look for other tab as Comfortis Plus does it all



Great product, fast delivery, I always use Vetsupply


Comfortis Plus

Been using for a number of years. Great product and fast delivery.



one dose of this liquid protects my pet from all the flea trouble

Have A Question?
Q: Can comfortis plus be swallowed whole without chewing first

A: COMFORTIS PLUS may be offered in food or administered like other tablet medications, in conjunction with a meal. For maximum effectiveness, it is recommended to be administered with food.

By, on Jul 20, 2022
0 2
Q: Can comfortis plus be used on cats?

A: It is not advisable to use any product indicated for dogs on cats.

By, on Jul 08, 2022
0 1
Q: Is this breed specific?

A: No

By, on Apr 23, 2022
2 3
Q: What to use for tapeworm?

A: Virbac Tapewormer

By, on Mar 21, 2022
3 4
Q: Is it safe for dogs not tested for heartworm

A: Yes

By, on Mar 21, 2022
2 4
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